{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eden ER"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["473-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4906250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(5)"],"pubmed_abstract":["Membrane contact sites between the ER and multivesicular endosomes/bodies (MVBs) play important roles in endosome positioning and fission and in neurite outgrowth. ER-MVB contacts additionally function in epidermal growth factor receptor (EGFR) tyrosine kinase downregulation by providing sites where the ER-localized phosphatase, PTP1B, interacts with endocytosed EGFR before the receptor is sorted onto intraluminal vesicles (ILVs). Here we show that these contacts are tethered by annexin A1 and its Ca(2+)-dependent ligand, S100A11, and form a subpopulation of differentially regulated contact sites between the ER and endocytic organelles. Annexin A1-regulated contacts function in the transfer of ER-derived cholesterol to the MVB when low-density lipoprotein-cholesterol in endosomes is low. T"],"journal":["Developmental cell"],"pubmed_title":["Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport."],"pmcid":["PMC4906250"],"funding_grant_id":["G0801878","M010767","093445","MR/M010767/1"],"pubmed_authors":["Eden ER","Tsapara A","Sobota A","Sanchez-Heras E","Levine TP","Futter CE"],"additional_accession":[]},"is_claimable":false,"name":"Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport.","description":"Membrane contact sites between the ER and multivesicular endosomes/bodies (MVBs) play important roles in endosome positioning and fission and in neurite outgrowth. ER-MVB contacts additionally function in epidermal growth factor receptor (EGFR) tyrosine kinase downregulation by providing sites where the ER-localized phosphatase, PTP1B, interacts with endocytosed EGFR before the receptor is sorted onto intraluminal vesicles (ILVs). Here we show that these contacts are tethered by annexin A1 and its Ca(2+)-dependent ligand, S100A11, and form a subpopulation of differentially regulated contact sites between the ER and endocytic organelles. Annexin A1-regulated contacts function in the transfer of ER-derived cholesterol to the MVB when low-density lipoprotein-cholesterol in endosomes is low. T","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-05T16:17:38.774Z","creation":"2019-03-27T02:15:58Z"},"accession":"S-EPMC4906250","cross_references":{"pubmed":["27270042"],"doi":["10.1016/j.devcel.2016.05.005"]}}