{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Herrera VL"],"funding":["NCATS NIH HHS","National Cancer Institute","BU CTSI award","NCI NIH HHS","BU Office of Technology Development"],"pagination":["15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4906906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in automated DNA and RNA sequences. However, re-analysis is needed given prior single gene studies detected a tryptophan [TGG]-codon#14 by manual Sanger sequencing, demonstrated DEspR translatability and functionality, and since the demonstration of actual non-translatability through expression studies, the standard-of-excellence for pseudogene designation, has not been performed. Re-analysis must meet UNIPROT criteria for demonstration of a protein's existence at the highest (protein) level, which a priori, would override DNA- or RNA-based deductions.<h4>Methods</h"],"journal":["BMC molecular biology"],"pubmed_title":["Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein."],"pmcid":["PMC4906906"],"funding_grant_id":["5P30CA045508","P30 CA045508","U54 TR001012","NIH-U54TR001012"],"pubmed_authors":["Steffen M","Ruiz-Opazo N","Pappin DJ","Tan GA","Pasion KA","Herrera VL","Moran AM","Rivera K"],"additional_accession":[]},"is_claimable":false,"name":"Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein.","description":"<h4>Background</h4>In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 in automated DNA and RNA sequences. However, re-analysis is needed given prior single gene studies detected a tryptophan [TGG]-codon#14 by manual Sanger sequencing, demonstrated DEspR translatability and functionality, and since the demonstration of actual non-translatability through expression studies, the standard-of-excellence for pseudogene designation, has not been performed. Re-analysis must meet UNIPROT criteria for demonstration of a protein's existence at the highest (protein) level, which a priori, would override DNA- or RNA-based deductions.<h4>Methods</h","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-06-15T07:05:34.119Z","creation":"2019-03-27T02:15:59Z"},"accession":"S-EPMC4906906","cross_references":{"pubmed":["27301377"],"doi":["10.1186/s12867-016-0066-8"]}}