biostudies-literatureKlein KRNIDDK NIH HHSNHLBI NIH HHS65-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC4911013biostudies-literatureUnknown51(1)Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.Critical reviews in biochemistry and molecular biologyThe expanding repertoire of receptor activity modifying protein (RAMP) function.PMC4911013DK099156R01 DK099156F30 HL118932Klein KRMatson BCCaron KMfalseThe expanding repertoire of receptor activity modifying protein (RAMP) function.Receptor activity modifying proteins (RAMPs) associate with G-protein-coupled receptors (GPCRs) at the plasma membrane and together bind a variety of peptide ligands, serving as a communication interface between the extracellular and intracellular environments. The collection of RAMP-interacting GPCRs continues to expand and now consists of GPCRs from families A, B and C, suggesting that RAMP activity is extremely prevalent. RAMP association with GPCRs can regulate GPCR function by altering ligand binding, receptor trafficking and desensitization, and downstream signaling pathways. Here, we elaborate on these RAMP-dependent mechanisms of GPCR regulation, which provide opportunities for pharmacological intervention.2016-01-01T00:00:00Z2016 Jan-Feb2021-02-19T11:51:57Z2019-03-27T02:16:14ZS-EPMC49110132674045710.3109/10409238.2015.1128875