{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Swaims-Kohlmeier A"],"funding":["NCATS NIH HHS","NICHD NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIH HHS"],"pagination":["368-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4912879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["197(1)"],"pubmed_abstract":["The female genital tract (FGT) provides a means of entry to pathogens, including HIV, yet immune cell populations at this barrier between host and environment are not well defined. We initiated a study of healthy women to characterize resident T cell populations in the lower FGT from lavage and patient-matched peripheral blood to investigate potential mechanisms of HIV sexual transmission. Surprisingly, we observed FGT CD4 T cell populations were primarily CCR7(hi), consistent with a central memory or recirculating memory T cell phenotype. In addition, roughly half of these CCR7(hi) CD4 T cells expressed CD69, consistent with resident memory T cells, whereas the remaining CCR7(hi) CD4 T cells lacked CD69 expression, consistent with recirculating memory CD4 T cells that traffic between peri"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential."],"pmcid":["PMC4912879"],"funding_grant_id":["R01 HL122559","K23 AI114407","UL1 TR000454","K23 HD078153","P51 OD011132","KL2 TR000455","TL1 TR000456","P30 AI050409"],"pubmed_authors":["Cordes S","Hart CE","Kohlmeier JE","Haaland RE","Lupo LD","Lupoli KA","Ofotukun I","Haddad LB","Chen CY","Evans-Strickfaden T","Swaims-Kohlmeier A","Sheth AN","Aguirre AJ"],"additional_accession":[]},"is_claimable":false,"name":"Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.","description":"The female genital tract (FGT) provides a means of entry to pathogens, including HIV, yet immune cell populations at this barrier between host and environment are not well defined. We initiated a study of healthy women to characterize resident T cell populations in the lower FGT from lavage and patient-matched peripheral blood to investigate potential mechanisms of HIV sexual transmission. Surprisingly, we observed FGT CD4 T cell populations were primarily CCR7(hi), consistent with a central memory or recirculating memory T cell phenotype. In addition, roughly half of these CCR7(hi) CD4 T cells expressed CD69, consistent with resident memory T cells, whereas the remaining CCR7(hi) CD4 T cells lacked CD69 expression, consistent with recirculating memory CD4 T cells that traffic between peri","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2025-04-04T07:28:23.933Z","creation":"2019-03-27T02:16:23Z"},"accession":"S-EPMC4912879","cross_references":{"pubmed":["27233960"],"doi":["10.4049/jimmunol.1502628"]}}