biostudies-literatureSwaims-Kohlmeier ANCATS NIH HHSNICHD NIH HHSNIAID NIH HHSNHLBI NIH HHSNIH HHS368-76https://www.ebi.ac.uk/biostudies/studies/S-EPMC4912879biostudies-literatureUnknown197(1)The female genital tract (FGT) provides a means of entry to pathogens, including HIV, yet immune cell populations at this barrier between host and environment are not well defined. We initiated a study of healthy women to characterize resident T cell populations in the lower FGT from lavage and patient-matched peripheral blood to investigate potential mechanisms of HIV sexual transmission. Surprisingly, we observed FGT CD4 T cell populations were primarily CCR7(hi), consistent with a central memory or recirculating memory T cell phenotype. In addition, roughly half of these CCR7(hi) CD4 T cells expressed CD69, consistent with resident memory T cells, whereas the remaining CCR7(hi) CD4 T cells lacked CD69 expression, consistent with recirculating memory CD4 T cells that traffic between periJournal of immunology (Baltimore, Md. : 1950)Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.PMC4912879R01 HL122559K23 AI114407UL1 TR000454K23 HD078153P51 OD011132KL2 TR000455TL1 TR000456P30 AI050409Cordes SHart CEKohlmeier JEHaaland RELupo LDLupoli KAOfotukun IHaddad LBChen CYEvans-Strickfaden TSwaims-Kohlmeier ASheth ANAguirre AJfalseProgesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential.The female genital tract (FGT) provides a means of entry to pathogens, including HIV, yet immune cell populations at this barrier between host and environment are not well defined. We initiated a study of healthy women to characterize resident T cell populations in the lower FGT from lavage and patient-matched peripheral blood to investigate potential mechanisms of HIV sexual transmission. Surprisingly, we observed FGT CD4 T cell populations were primarily CCR7(hi), consistent with a central memory or recirculating memory T cell phenotype. In addition, roughly half of these CCR7(hi) CD4 T cells expressed CD69, consistent with resident memory T cells, whereas the remaining CCR7(hi) CD4 T cells lacked CD69 expression, consistent with recirculating memory CD4 T cells that traffic between peri2016-01-01T00:00:00Z2016 Jul2025-04-04T07:28:23.933Z2019-03-27T02:16:23ZS-EPMC49128792723396010.4049/jimmunol.1502628