{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Papaemmanuil E"],"funding":["Cancer Research UK","Medical Research Council","Wellcome Trust"],"pagination":["1006-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4915548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(9)"],"pubmed_abstract":["To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)). The 10q21.2 (ARID5B) risk association appears to be selective for the subset of B-cell precursor ALL with hyperdiploidy. These data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological"],"journal":["Nature genetics"],"pubmed_title":["Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia."],"pmcid":["PMC4915548"],"funding_grant_id":["G0000934","C1298/A8362","068545"],"pubmed_authors":["Vijayakrishnan J","Lightfoot T","Greaves M","Hosking FJ","Kinsey SE","Papaemmanuil E","Olver B","Taylor M","Irving JA","Roman E","Allan JM","Tomlinson IP","Sheridan E","Price A","Houlston RS"],"additional_accession":[]},"is_claimable":false,"name":"Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.","description":"To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)). The 10q21.2 (ARID5B) risk association appears to be selective for the subset of B-cell precursor ALL with hyperdiploidy. These data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Sep","modification":"2026-05-05T08:52:16.052Z","creation":"2019-03-27T02:16:37Z"},"accession":"S-EPMC4915548","cross_references":{"pubmed":["19684604"],"doi":["10.1038/ng.430"]}}