{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(12)"],"submitter":["Breiman A"],"pubmed_abstract":["Terminal fucosylated motifs of glycoproteins and glycolipid chains are often altered in cancer cells. We investigated the link between fucosylation changes and critical steps in cancer progression: epithelial-to-mesenchymal transition (EMT) and lymph node metastasis.Using mammary cell lines, we demonstrate that during EMT, expression of some fucosylated antigens (e.g.: Lewis Y) is decreased as a result of repression of the fucosyltransferase genes FUT1 and FUT3. Moreover, we identify the fucose-binding bacterial lectin BC2L-C-Nt as a specific probe for the epithelial state.Prolectin (CLEC17A), a human lectin found on lymph node B cells, shares ligand specificities with BC2L-C-Nt. It binds preferentially to epithelial rather than to mesenchymal cells, and microfluidic experiments showed tha"],"journal":["Oncotarget"],"pagination":["14064-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4924698"],"repository":["biostudies-literature"],"pubmed_title":["Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin)."],"pmcid":["PMC4924698"],"pubmed_authors":["Barille-Nion S","Le Pendu J","Lopez Robles MD","Echasserieau K","de Carne Trecesson S","Altare F","Breiman A","Bernardeau K","Drickamer K","Imberty A"],"additional_accession":[]},"is_claimable":false,"name":"Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin).","description":"Terminal fucosylated motifs of glycoproteins and glycolipid chains are often altered in cancer cells. We investigated the link between fucosylation changes and critical steps in cancer progression: epithelial-to-mesenchymal transition (EMT) and lymph node metastasis.Using mammary cell lines, we demonstrate that during EMT, expression of some fucosylated antigens (e.g.: Lewis Y) is decreased as a result of repression of the fucosyltransferase genes FUT1 and FUT3. Moreover, we identify the fucose-binding bacterial lectin BC2L-C-Nt as a specific probe for the epithelial state.Prolectin (CLEC17A), a human lectin found on lymph node B cells, shares ligand specificities with BC2L-C-Nt. It binds preferentially to epithelial rather than to mesenchymal cells, and microfluidic experiments showed tha","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2026-05-05T09:50:20.691Z","creation":"2019-03-27T02:17:06Z"},"accession":"S-EPMC4924698","cross_references":{"pubmed":["26908442"],"doi":["10.18632/oncotarget.7476"]}}