{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beneri CA"],"funding":["NCRR NIH HHS","NIAID NIH HHS"],"pagination":["93-100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4928853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Setting</h4>Standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification.<h4>Objective</h4>To apply published guidelines for intrathoracic TB classification for use in reporting diagnostic studies with passive case finding to presumed TB patients from International Maternal Pediatric Adolescent AIDS Clinical Trials P1041, a trial of isoniazid prophylaxis in healthy human immunodeficiency virus exposed, bacille Calmette-Guérin vaccinated infants which employed active surveillance to assess a novel application of these guidelines in this setting.<h4>Methods</h4>P1041 presumed TB patients were retrospectively cross-classified by protocol-defined and National Institutes of Health (NIH) classifications, and agreement w"],"journal":["The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease"],"pubmed_title":["Understanding NIH clinical case definitions for pediatric intrathoracic TB by applying them to a clinical trial."],"pmcid":["PMC4928853"],"funding_grant_id":["UM1 AI069456","M01 RR016587","UM1 AI068632","UM1 AI106716","UM1AI068616","UM1 AI068634","UM1AI106716","UM1 AI068616","UM1AI068632","HHSN272200800014C","UM1 AI069453"],"pubmed_authors":["Kim S","Cotton MF","Madhi S","Beneri CA","Aaron L","Mitchell C","Violari A","P1041 team","Jean-Philippe P","Nachman S"],"additional_accession":[]},"is_claimable":false,"name":"Understanding NIH clinical case definitions for pediatric intrathoracic TB by applying them to a clinical trial.","description":"<h4>Setting</h4>Standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification.<h4>Objective</h4>To apply published guidelines for intrathoracic TB classification for use in reporting diagnostic studies with passive case finding to presumed TB patients from International Maternal Pediatric Adolescent AIDS Clinical Trials P1041, a trial of isoniazid prophylaxis in healthy human immunodeficiency virus exposed, bacille Calmette-Guérin vaccinated infants which employed active surveillance to assess a novel application of these guidelines in this setting.<h4>Methods</h4>P1041 presumed TB patients were retrospectively cross-classified by protocol-defined and National Institutes of Health (NIH) classifications, and agreement w","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T02:04:53.149Z","creation":"2019-03-27T02:17:18Z"},"accession":"S-EPMC4928853","cross_references":{"pubmed":["26688534"],"doi":["10.5588/ijtld.14.0848"]}}