biostudies-literatureBeneri CANCRR NIH HHSNIAID NIH HHS93-100https://www.ebi.ac.uk/biostudies/studies/S-EPMC4928853biostudies-literatureUnknown20(1)<h4>Setting</h4>Standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification.<h4>Objective</h4>To apply published guidelines for intrathoracic TB classification for use in reporting diagnostic studies with passive case finding to presumed TB patients from International Maternal Pediatric Adolescent AIDS Clinical Trials P1041, a trial of isoniazid prophylaxis in healthy human immunodeficiency virus exposed, bacille Calmette-Guérin vaccinated infants which employed active surveillance to assess a novel application of these guidelines in this setting.<h4>Methods</h4>P1041 presumed TB patients were retrospectively cross-classified by protocol-defined and National Institutes of Health (NIH) classifications, and agreement wThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung DiseaseUnderstanding NIH clinical case definitions for pediatric intrathoracic TB by applying them to a clinical trial.PMC4928853UM1 AI069456M01 RR016587UM1 AI068632UM1 AI106716UM1AI068616UM1 AI068634UM1AI106716UM1 AI068616UM1AI068632HHSN272200800014CUM1 AI069453Kim SCotton MFMadhi SBeneri CAAaron LMitchell CViolari AP1041 teamJean-Philippe PNachman SfalseUnderstanding NIH clinical case definitions for pediatric intrathoracic TB by applying them to a clinical trial.<h4>Setting</h4>Standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification.<h4>Objective</h4>To apply published guidelines for intrathoracic TB classification for use in reporting diagnostic studies with passive case finding to presumed TB patients from International Maternal Pediatric Adolescent AIDS Clinical Trials P1041, a trial of isoniazid prophylaxis in healthy human immunodeficiency virus exposed, bacille Calmette-Guérin vaccinated infants which employed active surveillance to assess a novel application of these guidelines in this setting.<h4>Methods</h4>P1041 presumed TB patients were retrospectively cross-classified by protocol-defined and National Institutes of Health (NIH) classifications, and agreement w2016-01-01T00:00:00Z2016 Jan2025-04-04T02:04:53.149Z2019-03-27T02:17:18ZS-EPMC49288532668853410.5588/ijtld.14.0848