{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(7)"],"submitter":["Roszkowski M"],"pubmed_abstract":["Several studies have reported that exposure to acute psychophysiological stressors can lead to an increase in blood-brain barrier permeability, but these findings remain controversial and disputed. We thoroughly examined this issue by assessing the effect of several well-established paradigms of acute stress and chronic stress on blood-brain barrier permeability in several brain areas of adult mice. Using cerebral extraction ratio for the small molecule tracer sodium fluorescein (NaF, 376 Da) as a sensitive measure of blood-brain barrier permeability, we find that neither acute swim nor restraint stress lead to increased cerebral extraction ratio. Daily 6-h restraint stress for 21 days, a model for the severe detrimental impact of chronic stress on brain function, also does not alter cereb"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pagination":["1304-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4929709"],"repository":["biostudies-literature"],"pubmed_title":["Stress does not increase blood-brain barrier permeability in mice."],"pmcid":["PMC4929709"],"pubmed_authors":["Bohacek J","Roszkowski M"],"additional_accession":[]},"is_claimable":false,"name":"Stress does not increase blood-brain barrier permeability in mice.","description":"Several studies have reported that exposure to acute psychophysiological stressors can lead to an increase in blood-brain barrier permeability, but these findings remain controversial and disputed. We thoroughly examined this issue by assessing the effect of several well-established paradigms of acute stress and chronic stress on blood-brain barrier permeability in several brain areas of adult mice. Using cerebral extraction ratio for the small molecule tracer sodium fluorescein (NaF, 376 Da) as a sensitive measure of blood-brain barrier permeability, we find that neither acute swim nor restraint stress lead to increased cerebral extraction ratio. Daily 6-h restraint stress for 21 days, a model for the severe detrimental impact of chronic stress on brain function, also does not alter cereb","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2026-05-05T14:57:36.347Z","creation":"2019-03-27T02:17:21Z"},"accession":"S-EPMC4929709","cross_references":{"pubmed":["27146513"],"doi":["10.1177/0271678X16647739","10.1177/0271678x16647739"]}}