{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wiberg S"],"funding":["The Danish Heart Foundation","The Research Foundation from the Heart Centre, Copenhagen University Hospital"],"pagination":["304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4929765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Attenuating the neurological damage occurring after out-of-hospital cardiac arrest is an ongoing research effort. This dual-centre study investigates the neuroprotective effects of the glucagon-like-peptide-1 analogue Exenatide administered within 4 hours from the return of spontaneous circulation to comatose patients resuscitated from out-of-hospital cardiac arrest.<h4>Methods/design</h4>This pilot study will randomize a total of 120 unconscious patients with sustained return of spontaneous circulation after out-of-hospital cardiac arrest undergoing targeted temperature management in a blinded one-to-one fashion to a 6-hour and 15-minute infusion of either Exenatide or placebo. Patients are eligible for inclusion if resuscitated from cardiac arrest with randomization fr"],"journal":["Trials"],"pubmed_title":["GLP-1 analogues for neuroprotection after out-of-hospital cardiac arrest: study protocol for a randomized controlled trial."],"pmcid":["PMC4929765"],"funding_grant_id":["14-R97-A5326-22819"],"pubmed_authors":["Engstrom T","Hofsten DE","Hassager C","Kober L","Wiberg S","Thomsen JH","Moller JE","Frydland M","Schmidt H","Kjaergaard J"],"additional_accession":[]},"is_claimable":false,"name":"GLP-1 analogues for neuroprotection after out-of-hospital cardiac arrest: study protocol for a randomized controlled trial.","description":"<h4>Background</h4>Attenuating the neurological damage occurring after out-of-hospital cardiac arrest is an ongoing research effort. This dual-centre study investigates the neuroprotective effects of the glucagon-like-peptide-1 analogue Exenatide administered within 4 hours from the return of spontaneous circulation to comatose patients resuscitated from out-of-hospital cardiac arrest.<h4>Methods/design</h4>This pilot study will randomize a total of 120 unconscious patients with sustained return of spontaneous circulation after out-of-hospital cardiac arrest undergoing targeted temperature management in a blinded one-to-one fashion to a 6-hour and 15-minute infusion of either Exenatide or placebo. Patients are eligible for inclusion if resuscitated from cardiac arrest with randomization fr","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-06-16T05:09:18.7Z","creation":"2019-03-27T02:17:21Z"},"accession":"S-EPMC4929765","cross_references":{"pubmed":["27363489"],"doi":["10.1186/s13063-016-1421-2"]}}