{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Chen J"],"pubmed_abstract":["Single-cell RNA-sequencing offers unprecedented resolution of the continuum of state transition during cell differentiation and development. However, tools for constructing multi-branching cell lineages from single-cell data are limited. Here we present Mpath, an algorithm that derives multi-branching developmental trajectories using neighborhood-based cell state transitions. Applied to mouse conventional dendritic cell (cDC) progenitors, Mpath constructs multi-branching trajectories spanning from macrophage/DC progenitors through common DC progenitor to pre-dendritic cells (preDC). The Mpath-generated trajectories detect a branching event at the preDC stage revealing preDC subsets that are exclusively committed to cDC1 or cDC2 lineages. Reordering cells along cDC development reveals seque"],"journal":["Nature communications"],"pagination":["11988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4931327"],"repository":["biostudies-literature"],"pubmed_title":["Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development."],"pmcid":["PMC4931327"],"pubmed_authors":["Ginhoux F","Chen J","Schlitzer A","Poidinger M","Chakarov S"],"additional_accession":[]},"is_claimable":false,"name":"Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development.","description":"Single-cell RNA-sequencing offers unprecedented resolution of the continuum of state transition during cell differentiation and development. However, tools for constructing multi-branching cell lineages from single-cell data are limited. Here we present Mpath, an algorithm that derives multi-branching developmental trajectories using neighborhood-based cell state transitions. Applied to mouse conventional dendritic cell (cDC) progenitors, Mpath constructs multi-branching trajectories spanning from macrophage/DC progenitors through common DC progenitor to pre-dendritic cells (preDC). The Mpath-generated trajectories detect a branching event at the preDC stage revealing preDC subsets that are exclusively committed to cDC1 or cDC2 lineages. Reordering cells along cDC development reveals seque","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-04T10:43:21.069Z","creation":"2019-03-27T02:17:27Z"},"accession":"S-EPMC4931327","cross_references":{"pubmed":["27356503"],"doi":["10.1038/ncomms11988"]}}