biostudies-literature00600Liu YNational Natural Science Foundation of China206https://www.ebi.ac.uk/biostudies/studies/S-EPMC4932686biostudies-literatureUnknown16<h4>Background</h4>Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.<h4>Methods</h4>We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.<h4>Results</h4>No significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).<h4>Conclusions</h4>Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.BMC psychiatryNo association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.PMC493268681471364Liu YZhang FJin CWang GWang JYuan JCheng ZZhao X60falseNo association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.<h4>Background</h4>Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.<h4>Methods</h4>We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.<h4>Results</h4>No significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).<h4>Conclusions</h4>Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.2016-01-01T00:00:00Z2016 Jul2024-11-12T12:32:40.617Z2019-03-27T02:17:33ZS-EPMC49326862737775410.1186/s12888-016-0923-5