{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Valtorta NK"],"funding":["National Institute for Health Research (NIHR)"],"pagination":["1009-16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4941172"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(13)"],"pubmed_abstract":["<h4>Background</h4>The influence of social relationships on morbidity is widely accepted, but the size of the risk to cardiovascular health is unclear.<h4>Objective</h4>We undertook a systematic review and meta-analysis to investigate the association between loneliness or social isolation and incident coronary heart disease (CHD) and stroke.<h4>Methods</h4>Sixteen electronic databases were systematically searched for longitudinal studies set in high-income countries and published up until May 2015. Two independent reviewers screened studies for inclusion and extracted data. We assessed quality using a component approach and pooled data for analysis using random effects models.<h4>Results</h4>Of the 35 925 records retrieved, 23 papers met inclusion criteria for the narrative review. They re"],"journal":["Heart (British Cardiac Society)"],"pubmed_title":["Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies."],"pmcid":["PMC4941172"],"funding_grant_id":["DRF-2013-06-074"],"pubmed_authors":["Valtorta NK","Gilbody S","Ronzi S","Hanratty B","Kanaan M"],"additional_accession":[]},"is_claimable":false,"name":"Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies.","description":"<h4>Background</h4>The influence of social relationships on morbidity is widely accepted, but the size of the risk to cardiovascular health is unclear.<h4>Objective</h4>We undertook a systematic review and meta-analysis to investigate the association between loneliness or social isolation and incident coronary heart disease (CHD) and stroke.<h4>Methods</h4>Sixteen electronic databases were systematically searched for longitudinal studies set in high-income countries and published up until May 2015. Two independent reviewers screened studies for inclusion and extracted data. We assessed quality using a component approach and pooled data for analysis using random effects models.<h4>Results</h4>Of the 35 925 records retrieved, 23 papers met inclusion criteria for the narrative review. They re","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2026-07-15T21:35:20.402Z","creation":"2026-07-09T10:14:05.837Z"},"accession":"S-EPMC4941172","cross_references":{"pubmed":["27091846"],"doi":["10.1136/heartjnl-2015-308790"]}}