{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng YH"],"funding":["National Natural Science Foundation of China"],"pagination":["1388-96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4944864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(7)"],"pubmed_abstract":["Esophageal squamous cell carcinoma (ESCC) can be treated effectively if diagnosed at an early stage. We evaluated whether measurement of Dickkopf-1 (DKK-1) in combination of DKK-1 autoantibodies in serum may benefit early diagnosis of ESCC. Serum DKK-1 and DKK-1 autoantibodies were measured by enzyme-linked immunosorbent assay in a training cohort (185 ESCC samples vs. 97 normal controls) and validated in a validation cohort (104 ESCC samples vs. 53 normal controls). Receiver operating characteristic (ROC) was applied to calculate diagnostic accuracy. Testing of DKK-1 and DKK-1 autoantibodies together could differentiate ESCC from normal controls (area under the ROC curve [AUC] 0.769, 95% confidence interval (CI), 0.715-0.823, 50.3% sensitivity, and 90.7% specificity in the training cohort"],"journal":["Cancer medicine"],"pubmed_title":["Combined detection of serum Dickkopf-1 and its autoantibodies to diagnose esophageal squamous cell carcinoma."],"pmcid":["PMC4944864"],"funding_grant_id":["81172264","81472613"],"pubmed_authors":["Tan HZ","Li EM","Guo H","Hong CQ","Peng YH","Huang LS","Xu YW","Li SS","Xu LY"],"additional_accession":[]},"is_claimable":false,"name":"Combined detection of serum Dickkopf-1 and its autoantibodies to diagnose esophageal squamous cell carcinoma.","description":"Esophageal squamous cell carcinoma (ESCC) can be treated effectively if diagnosed at an early stage. We evaluated whether measurement of Dickkopf-1 (DKK-1) in combination of DKK-1 autoantibodies in serum may benefit early diagnosis of ESCC. Serum DKK-1 and DKK-1 autoantibodies were measured by enzyme-linked immunosorbent assay in a training cohort (185 ESCC samples vs. 97 normal controls) and validated in a validation cohort (104 ESCC samples vs. 53 normal controls). Receiver operating characteristic (ROC) was applied to calculate diagnostic accuracy. Testing of DKK-1 and DKK-1 autoantibodies together could differentiate ESCC from normal controls (area under the ROC curve [AUC] 0.769, 95% confidence interval (CI), 0.715-0.823, 50.3% sensitivity, and 90.7% specificity in the training cohort","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2025-04-18T18:10:07.298Z","creation":"2019-03-27T02:18:21Z"},"accession":"S-EPMC4944864","cross_references":{"pubmed":["26988995"],"doi":["10.1002/cam4.702"]}}