biostudies-literature00670Inouye SKNIA NIH HHSNational Institute on Aging766-75https://www.ebi.ac.uk/biostudies/studies/S-EPMC4947419biostudies-literatureUnknown12(7)<h4>Introduction</h4>As the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study.<h4>Methods</h4>SAGES is an ongoing study involving 560 adults age 70 years or more without dementia scheduled for major surgery. Delirium was assessed daily in the postoperative period using the Confusion Assessment Method. General Cognitive Performance (GCP) and the Informant Questionnaire for Cognitive Decline in the Elderly were assessed preoperatively then repeatedly out to 36 months.<h4>Results</h4>On average, patients with postoperative delirium had significantly lower preoperative cognitive performance, greater immediate (1 month) impairment, equivalent recovery at 2 months, and significantly greater long-term cognitive decline relative to the nondelirium group. Proxy reports corroborated the clinical significance of the long-term cognitive decline in delirious patients.<h4>Discussion</h4>Cognitive decline after surgery is biphasic and accelerated among persons with delirium. The pace of long-term decline is similar to that seen with mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's AssociationThe short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients.PMC4947419R01AG044518K24 AG035075K07 AG041835P01AG031720R01 AG044518K07AG041835K24AG035075R01 AG030618P01 AG031720R01AG030618Saczynski JSTravison TGInouye SKJones RNTommet DSchmitt EMMarcantonio ERAlsop DCKosar CMNgo LH67falseThe short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients.<h4>Introduction</h4>As the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study.<h4>Methods</h4>SAGES is an ongoing study involving 560 adults age 70 years or more without dementia scheduled for major surgery. Delirium was assessed daily in the postoperative period using the Confusion Assessment Method. General Cognitive Performance (GCP) and the Informant Questionnaire for Cognitive Decline in the Elderly were assessed preoperatively then repeatedly out to 36 months.<h4>Results</h4>On average, patients with postoperative delirium had significantly lower preoperative cognitive performance, greater immediate (1 month) impairment, equivalent recovery at 2 months, and significantly greater long-term cognitive decline relative to the nondelirium group. Proxy reports corroborated the clinical significance of the long-term cognitive decline in delirious patients.<h4>Discussion</h4>Cognitive decline after surgery is biphasic and accelerated among persons with delirium. The pace of long-term decline is similar to that seen with mild cognitive impairment.2016-01-01T00:00:00Z2016 Jul2024-11-21T03:52:21.372Z2019-03-27T02:18:31ZS-EPMC49474192710326110.1016/j.jalz.2016.03.005