{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brigden A"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["e011255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4947787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(7)"],"pubmed_abstract":["Introduction
Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery for paediatric CFS/ME. This study aims to investigate the acceptability and feasibility of carrying out a multicentre randomised controlled trial investigating the effectiveness of graded exercise therapy compared with activity management for children/teenagers who are mildly or moderately affected with CFS/ME.Methods and analysis
100 paediatric patients (8-17 years) with CFS/ME wil"],"journal":["BMJ open"],"pubmed_title":["Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol."],"pmcid":["PMC4947787"],"funding_grant_id":["Senior Research Fellowship, Dr Esther Crawley, SRF","SRF-2013-06-013","MR/K023233/1","NF-SI-0514-10114","CS/08/08/06","MR/L004933/2","MR/L004933/1","MR/K025643/1"],"pubmed_authors":["Hollingworth W","Beasant L","Gaunt D","Mills N","Metcalfe C","Brigden A","Jago R","Crawley E"],"additional_accession":[]},"is_claimable":false,"name":"Managed Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol.","description":"Introduction
Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery for paediatric CFS/ME. This study aims to investigate the acceptability and feasibility of carrying out a multicentre randomised controlled trial investigating the effectiveness of graded exercise therapy compared with activity management for children/teenagers who are mildly or moderately affected with CFS/ME.Methods and analysis
100 paediatric patients (8-17 years) with CFS/ME wil","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2026-07-15T16:31:59.345Z","creation":"2026-07-07T03:08:36.103Z"},"accession":"S-EPMC4947787","cross_references":{"pubmed":["27377634"],"doi":["10.1136/bmjopen-2016-011255"]}}