biostudies-literatureBrigden AMedical Research CouncilNational Institute for Health Research (NIHR)e011255https://www.ebi.ac.uk/biostudies/studies/S-EPMC4947787biostudies-literatureUnknown6(7)<h4>Introduction</h4>Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery for paediatric CFS/ME. This study aims to investigate the acceptability and feasibility of carrying out a multicentre randomised controlled trial investigating the effectiveness of graded exercise therapy compared with activity management for children/teenagers who are mildly or moderately affected with CFS/ME.<h4>Methods and analysis</h4>100 paediatric patients (8-17 years) with CFS/ME wilBMJ openManaged Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol.PMC4947787Senior Research Fellowship, Dr Esther Crawley, SRFSRF-2013-06-013MR/K023233/1NF-SI-0514-10114CS/08/08/06MR/L004933/2MR/L004933/1MR/K025643/1Hollingworth WBeasant LGaunt DMills NMetcalfe CBrigden AJago RCrawley EfalseManaged Activity Graded Exercise iN Teenagers and pre-Adolescents (MAGENTA) feasibility randomised controlled trial: study protocol.<h4>Introduction</h4>Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery for paediatric CFS/ME. This study aims to investigate the acceptability and feasibility of carrying out a multicentre randomised controlled trial investigating the effectiveness of graded exercise therapy compared with activity management for children/teenagers who are mildly or moderately affected with CFS/ME.<h4>Methods and analysis</h4>100 paediatric patients (8-17 years) with CFS/ME wil2016-01-01T00:00:00Z2016 Jul2026-07-15T16:31:59.345Z2026-07-07T03:08:36.103ZS-EPMC49477872737763410.1136/bmjopen-2016-011255