{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vrshek-Schallhorn S"],"funding":["William T. Grant Foundation","Williams College","NIMH NIH HHS","UNCG","National Institute of Mental Health"],"pagination":["776-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4948188"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(4)"],"pubmed_abstract":["Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2). Analyses focused on 2 forms of interpersonal stress as environmental risk factors. Using 5 years of longitudinal diagnostic and life stress interviews from 387 emerging young adults in the Youth Emotion Project, survival analyses show "],"journal":["Journal of abnormal psychology"],"pubmed_title":["Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression."],"pmcid":["PMC4948188"],"funding_grant_id":["R01 MH065651","F32 MH091955","F32-MH091955","R01 MH065652","R01-MH065651","R01-MH065652"],"pubmed_authors":["Redei EE","Mineka S","Zinbarg RE","Craske MG","Stroud CB","Adam EK","Hammen C","Vrshek-Schallhorn S"],"additional_accession":[]},"is_claimable":false,"name":"Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.","description":"Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2). Analyses focused on 2 forms of interpersonal stress as environmental risk factors. Using 5 years of longitudinal diagnostic and life stress interviews from 387 emerging young adults in the Youth Emotion Project, survival analyses show ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2025-04-25T17:49:07.114Z","creation":"2019-03-27T02:18:34Z"},"accession":"S-EPMC4948188","cross_references":{"pubmed":["26595467"],"doi":["10.1037/abn0000098"]}}