biostudies-literatureVrshek-Schallhorn SWilliam T. Grant FoundationWilliams CollegeNIMH NIH HHSUNCGNational Institute of Mental Health776-90https://www.ebi.ac.uk/biostudies/studies/S-EPMC4948188biostudies-literatureUnknown124(4)Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2). Analyses focused on 2 forms of interpersonal stress as environmental risk factors. Using 5 years of longitudinal diagnostic and life stress interviews from 387 emerging young adults in the Youth Emotion Project, survival analyses show Journal of abnormal psychologyAdditive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.PMC4948188R01 MH065651F32 MH091955F32-MH091955R01 MH065652R01-MH065651R01-MH065652Redei EEMineka SZinbarg RECraske MGStroud CBAdam EKHammen CVrshek-Schallhorn SfalseAdditive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes HTR1A, HTR2A, HTR2C, and 2 in TPH2). Analyses focused on 2 forms of interpersonal stress as environmental risk factors. Using 5 years of longitudinal diagnostic and life stress interviews from 387 emerging young adults in the Youth Emotion Project, survival analyses show 2015-01-01T00:00:00Z2015 Nov2025-04-25T17:49:07.114Z2019-03-27T02:18:34ZS-EPMC49481882659546710.1037/abn0000098