{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Williams KJ"],"funding":["Medical Research Council","an MRC studentship","Biotechnology and Biological Sciences Research Council","Biotechnology and Biological Sciences Research Council, UK"],"pagination":["1142-57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4950008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["97(6)"],"pubmed_abstract":["A key component to the success of Mycobacterium tuberculosis as a pathogen is the ability to sense and adapt metabolically to the diverse range of conditions encountered in vivo, such as oxygen tension, environmental pH and nutrient availability. Although nitrogen is an essential nutrient for every organism, little is known about the genes and pathways responsible for nitrogen assimilation in M. tuberculosis. In this study we have used transcriptomics and chromatin immunoprecipitation and high-throughput sequencing to address this. In response to nitrogen starvation, a total of 185 genes were significantly differentially expressed (96 up-regulated and 89 down regulated; 5% genome) highlighting several significant areas of metabolic change during nitrogen limitation such as nitrate/nitrite "],"journal":["Molecular microbiology"],"pubmed_title":["Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress."],"pmcid":["PMC4950008"],"funding_grant_id":["BB/G020434/1","MR/J006874/1"],"pubmed_authors":["Williams KJ","Robertson BD","Jenkins VA","Barton GR","Bryant WA","Krishnan N"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress.","description":"A key component to the success of Mycobacterium tuberculosis as a pathogen is the ability to sense and adapt metabolically to the diverse range of conditions encountered in vivo, such as oxygen tension, environmental pH and nutrient availability. Although nitrogen is an essential nutrient for every organism, little is known about the genes and pathways responsible for nitrogen assimilation in M. tuberculosis. In this study we have used transcriptomics and chromatin immunoprecipitation and high-throughput sequencing to address this. In response to nitrogen starvation, a total of 185 genes were significantly differentially expressed (96 up-regulated and 89 down regulated; 5% genome) highlighting several significant areas of metabolic change during nitrogen limitation such as nitrate/nitrite ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-04-08T16:13:43.91Z","creation":"2019-03-27T02:18:43Z"},"accession":"S-EPMC4950008","cross_references":{"pubmed":["26077160"],"doi":["10.1111/mmi.13091"]}}