{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alreshidi MM"],"funding":["Harold Stannet Williams and Judith Mason Research Foundation","Gideon Lang Research Foundation","Ministry of Education and University of Hail"],"pagination":["e0159662"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4956324"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(7)"],"pubmed_abstract":["Staphylococcus aureus is an opportunistic pathogen responsible for a high proportion of nosocomial infections. This study was conducted to assess the bacterial responses in the cytoplasmic composition of amino acids and ribosomal proteins under various environmental conditions designed to mimic those on the human skin or within a wound site: pH6-8, temperature 35-37°C, and additional 0-5% NaCl. It was found that each set of environmental conditions elicited substantial adjustments in cytoplasmic levels of glutamic acid, aspartic acid, proline, alanine and glycine (P< 0.05). These alterations generated characteristic amino acid profiles assessed by principle component analysis (PCA). Substantial alterations in cytoplasmic amino acid and protein composition occurred during growth under condi"],"journal":["PloS one"],"pubmed_title":["Changes in the Cytoplasmic Composition of Amino Acids and Proteins Observed in Staphylococcus aureus during Growth under Variable Growth Conditions Representative of the Human Wound Site."],"pmcid":["PMC4956324"],"funding_grant_id":["PhD Scholarship, Saudi Arabia"],"pubmed_authors":["Macdonald MM","Williamson NA","Gottfries J","Dunstan RH","Crompton MJ","Roberts TK","Alreshidi MM","Ang CS"],"additional_accession":[]},"is_claimable":false,"name":"Changes in the Cytoplasmic Composition of Amino Acids and Proteins Observed in Staphylococcus aureus during Growth under Variable Growth Conditions Representative of the Human Wound Site.","description":"Staphylococcus aureus is an opportunistic pathogen responsible for a high proportion of nosocomial infections. This study was conducted to assess the bacterial responses in the cytoplasmic composition of amino acids and ribosomal proteins under various environmental conditions designed to mimic those on the human skin or within a wound site: pH6-8, temperature 35-37°C, and additional 0-5% NaCl. It was found that each set of environmental conditions elicited substantial adjustments in cytoplasmic levels of glutamic acid, aspartic acid, proline, alanine and glycine (P< 0.05). These alterations generated characteristic amino acid profiles assessed by principle component analysis (PCA). Substantial alterations in cytoplasmic amino acid and protein composition occurred during growth under condi","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-21T15:22:49.524Z","creation":"2019-03-26T22:52:21Z"},"accession":"S-EPMC4956324","cross_references":{"pubmed":["27442022"],"doi":["10.1371/journal.pone.0159662"]}}