biostudies-literatureUnknown8Salazar GFondazione IRCCS Ca׳ Granda Ospedale Maggiore PoliclinicoWe previously showed that Aminaphtone, a drug used in the treatment of chronic venous insufficiency, modulates several vasoactive factors, such as endothelin-1 and adhesion molecules. Here, we provide data of time-course experiments about the effects of Aminaphtone on gene expression at the genome-wide level in human endothelial cells undergoing cytokine stimulation in vitro. ECV-304 endothelial cells were incubated with interleukin-1β (IL-1β) in the presence or absence of Aminaphtone for 1, 3, and 6 h. Gene expression profiles were analyzed by microarray. This article contains complete data on the genes significantly modulated by the drug over time. The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1β stimulated endoData in brief836-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC4957571biostudies-literatureTime-course gene expression data on the transcriptional effects of Aminaphtone on ECV304 endothelial cells.PMC4957571Salazar GBellocchi CSaporiti FTodoerti KColombo GIPiacentini LScorza RfalseTime-course gene expression data on the transcriptional effects of Aminaphtone on ECV304 endothelial cells.We previously showed that Aminaphtone, a drug used in the treatment of chronic venous insufficiency, modulates several vasoactive factors, such as endothelin-1 and adhesion molecules. Here, we provide data of time-course experiments about the effects of Aminaphtone on gene expression at the genome-wide level in human endothelial cells undergoing cytokine stimulation in vitro. ECV-304 endothelial cells were incubated with interleukin-1β (IL-1β) in the presence or absence of Aminaphtone for 1, 3, and 6 h. Gene expression profiles were analyzed by microarray. This article contains complete data on the genes significantly modulated by the drug over time. The data are supplemental to our original research article reporting detailed analysis of the actions of Aminaphtone on IL-1β stimulated endo2016-01-01T00:00:00Z2016 Sep2026-04-30T02:44:19.058Z2019-03-27T02:18:58ZS-EPMC49575712750823010.1016/j.dib.2016.06.051