biostudies-literatureUnknown13(3)Larsen LEUniversitair Ziekenhuis GentBijzonder OnderzoeksfondsFonds Wetenschappelijk OnderzoekAlthough vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics592-602https://www.ebi.ac.uk/biostudies/studies/S-EPMC4965402biostudies-literatureVagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.PMC4965402Marinazzo DThyrion LSprengers MCarrette EBoon PLarsen LEDelbeke JVonck Kvan Mierlo PVan Lysebettens WRaedt RWadman WJDaelemans SfalseVagus Nerve Stimulation Applied with a Rapid Cycle Has More Profound Influence on Hippocampal Electrophysiology Than a Standard Cycle.Although vagus nerve stimulation (VNS) is widely used, therapeutic mechanisms and optimal stimulation parameters remain elusive. In the present study, we investigated the effect of VNS on hippocampal field activity and compared the efficiency of different VNS paradigms. Hippocampal electroencephalography (EEG) and perforant path dentate field-evoked potentials were acquired before and during VNS in freely moving rats, using 2 VNS duty cycles: a rapid cycle (7 s on, 18 s off) and standard cycle (30 s on, 300 s off) and various output currents. VNS modulated the evoked potentials, reduced total power of the hippocampal EEG, and slowed the theta rhythm. In the hippocampal EEG, theta (4-8 Hz) and high gamma (75-150 Hz) activity displayed strong phase amplitude coupling that was reduced by VNS.2016-01-01T00:00:00Z2016 Jul2025-05-29T22:26:41.989Z2025-05-29T22:26:41.989ZS-EPMC49654022710298710.1007/s13311-016-0432-8