{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fang S"],"funding":["NCI NIH HHS"],"pagination":["1741-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4966337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(15)"],"pubmed_abstract":["<h4>Purpose</h4>To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.<h4>Materials and methods</h4>Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.<h4>Results</h4>The median vitamin D level was 25.0 ng/m"],"journal":["Journal of clinical oncology : official journal of the American Society of Clinical Oncology"],"pubmed_title":["Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein."],"pmcid":["PMC4966337"],"funding_grant_id":["P30 CA023108","P30 CA016672","P50 CA093459"],"pubmed_authors":["Liu H","Wargo J","Lee JE","Sui D","Lucci A","Hu MI","Gershenwald JE","Reveille JD","Ross MI","Chiang YJ","Gardner JM","Amos CI","Wei Q","Bassett RL","Cormier JN","Fang S","Royal RE","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.","description":"<h4>Purpose</h4>To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.<h4>Materials and methods</h4>Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.<h4>Results</h4>The median vitamin D level was 25.0 ng/m","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-06-04T15:37:45.133Z","creation":"2019-03-27T02:19:28Z"},"accession":"S-EPMC4966337","cross_references":{"pubmed":["27001565"],"doi":["10.1200/jco.2015.64.1357","10.1200/JCO.2015.64.1357"]}}