biostudies-literatureFang SNCI NIH HHS1741-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4966337biostudies-literatureUnknown34(15)<h4>Purpose</h4>To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.<h4>Materials and methods</h4>Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.<h4>Results</h4>The median vitamin D level was 25.0 ng/mJournal of clinical oncology : official journal of the American Society of Clinical OncologyAssociation of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.PMC4966337P30 CA023108P30 CA016672P50 CA093459Liu HWargo JLee JESui DLucci AHu MIGershenwald JEReveille JDRoss MIChiang YJGardner JMAmos CIWei QBassett RLCormier JNFang SRoyal REWang YfalseAssociation of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.<h4>Purpose</h4>To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.<h4>Materials and methods</h4>Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date of blood draw. The vitamin D level was considered sufficient if it was 30 to 100 ng/mL. Kaplan-Meier and Cox regression analyses were performed.<h4>Results</h4>The median vitamin D level was 25.0 ng/m2016-01-01T00:00:00Z2016 May2026-06-04T15:37:45.133Z2019-03-27T02:19:28ZS-EPMC49663372700156510.1200/jco.2015.64.135710.1200/JCO.2015.64.1357