{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang YH"],"funding":["Swiss National Science Foundation"],"pagination":["1145-54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4967951"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(8)"],"pubmed_abstract":["Receptor kinases convey diverse environmental and developmental inputs by sensing extracellular ligands. In plants, one group of receptor-like kinases (RLKs) is characterized by extracellular leucine-rich repeat (LRR) domains, which interact with various ligands that include the plant hormone brassinosteroid and peptides of the CLAVATA3/EMBRYO SURROUNDING REGION (CLE) type. For instance, the CLE45 peptide requires the LRR-RLK BARELY ANY MERISTEM 3 (BAM3) to prevent protophloem formation in Arabidopsis root meristems. Here, we show that other proposed CLE45 receptors, the two redundantly acting LRR-RLKs STERILITY-REGULATING KINASE MEMBER 1 (SKM1) and SKM2 (which perceive CLE45 in the context of pollen tube elongation), cannot substitute for BAM3 in the root. Moreover, we identify MEMBRANE-A"],"journal":["EMBO reports"],"pubmed_title":["Arabidopsis MAKR5 is a positive effector of BAM3-dependent CLE45 signaling."],"pmcid":["PMC4967951"],"funding_grant_id":["147088","310030B_147088"],"pubmed_authors":["Hardtke CS","Kang YH"],"additional_accession":[]},"is_claimable":false,"name":"Arabidopsis MAKR5 is a positive effector of BAM3-dependent CLE45 signaling.","description":"Receptor kinases convey diverse environmental and developmental inputs by sensing extracellular ligands. In plants, one group of receptor-like kinases (RLKs) is characterized by extracellular leucine-rich repeat (LRR) domains, which interact with various ligands that include the plant hormone brassinosteroid and peptides of the CLAVATA3/EMBRYO SURROUNDING REGION (CLE) type. For instance, the CLE45 peptide requires the LRR-RLK BARELY ANY MERISTEM 3 (BAM3) to prevent protophloem formation in Arabidopsis root meristems. Here, we show that other proposed CLE45 receptors, the two redundantly acting LRR-RLKs STERILITY-REGULATING KINASE MEMBER 1 (SKM1) and SKM2 (which perceive CLE45 in the context of pollen tube elongation), cannot substitute for BAM3 in the root. Moreover, we identify MEMBRANE-A","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2026-05-05T15:42:14.602Z","creation":"2019-03-27T02:19:34Z"},"accession":"S-EPMC4967951","cross_references":{"pubmed":["27354416"],"doi":["10.15252/embr.201642450"]}}