{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bacelis J"],"funding":["Jane and Dan Olsson Foundations","March of Dimes Foundation (US)","Research Council of Norway","NINDS NIH HHS","Vetenskapsrådet (SE)"],"pagination":["e0160335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4973994"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["<h4>Background</h4>Five-to-eighteen percent of pregnancies worldwide end in preterm birth, which is the major cause of neonatal death and morbidity. Approximately 30% of the variation in gestational age at birth can be attributed to genetic factors. Genome-wide association studies (GWAS) have not shown robust evidence of association with genomic loci yet.<h4>Methods</h4>We separately investigated 1921 Norwegian mothers and 1199 children from pregnancies with spontaneous onset of delivery. Individuals were further divided based on the onset of delivery: initiated by labor or prelabor rupture of membranes. Genetic association with ultrasound-dated gestational age was evaluated using three genetic models and adaptive permutations. The top-ranked loci were tested for enrichment in 12 candidate"],"journal":["PloS one"],"pubmed_title":["Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways."],"pmcid":["PMC4973994"],"funding_grant_id":["FRIMEDBIO-249779","21-FY16-4341","VR-02559","U01 NS047537"],"pubmed_authors":["Juodakis J","Zhang G","Jacobsson B","Bacelis J","Myhre R","Sengpiel V","Muglia LJ","Nilsson S"],"additional_accession":[]},"is_claimable":false,"name":"Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways.","description":"<h4>Background</h4>Five-to-eighteen percent of pregnancies worldwide end in preterm birth, which is the major cause of neonatal death and morbidity. Approximately 30% of the variation in gestational age at birth can be attributed to genetic factors. Genome-wide association studies (GWAS) have not shown robust evidence of association with genomic loci yet.<h4>Methods</h4>We separately investigated 1921 Norwegian mothers and 1199 children from pregnancies with spontaneous onset of delivery. Individuals were further divided based on the onset of delivery: initiated by labor or prelabor rupture of membranes. Genetic association with ultrasound-dated gestational age was evaluated using three genetic models and adaptive permutations. The top-ranked loci were tested for enrichment in 12 candidate","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-07T14:57:06.011Z","creation":"2019-03-26T22:54:08Z"},"accession":"S-EPMC4973994","cross_references":{"pubmed":["27490719"],"doi":["10.1371/journal.pone.0160335"]}}