{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fleisch AF"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NIEHS NIH HHS","NIAID NIH HHS","Harvard School of Public Health","Harvard Pilgrim Health Care Institute","National Institutes of Health","Environmental Protection Agency"],"pagination":["48-57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4974151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown.<h4>Methods</h4>Among 1418 children in Project Viva, a Boston-area pre-birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid- (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM<sub>2.5</sub> and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics.<h4>Results</h4>Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid-childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid-childhood for children of mothers who lived <50 m vs. ≥200 m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM<sub>2.5</sub> exposure during the year prior was paradoxically associated with improved cardiometabolic profile.<h4>Conclusions</h4>Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health."],"journal":["Pediatric obesity"],"pubmed_title":["Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood."],"pmcid":["PMC4974151"],"funding_grant_id":["P01 ES009825","P30 DK092924","P30 ES000002","R01 AI102960","K23 ES024803","K12 DK094721","R37 HD034568","R01 HD034568","K24HD069408, R37HD034568, P30DK092924, P30ES000002, P01ES009825, R01AI102960, K12DK094721, K23ES024803","K24 HD069408","RD83479801\\"],"pubmed_authors":["Kloog I","Schwartz JD","Zanobetti A","Perng W","Oken E","Mantzoros CS","Gold DR","Gillman MW","Rifas-Shiman SL","Fleisch AF","Luttmann-Gibson H","Coull BA","Koutrakis P"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood.","description":"<h4>Background</h4>Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown.<h4>Methods</h4>Among 1418 children in Project Viva, a Boston-area pre-birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid- (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM<sub>2.5</sub> and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics.<h4>Results</h4>Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid-childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid-childhood for children of mothers who lived <50 m vs. ≥200 m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM<sub>2.5</sub> exposure during the year prior was paradoxically associated with improved cardiometabolic profile.<h4>Conclusions</h4>Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-26T22:00:47.24Z","creation":"2019-03-26T22:59:09Z"},"accession":"S-EPMC4974151","cross_references":{"pubmed":["26843357"],"doi":["10.1111/ijpo.12106"]}}