biostudies-literatureFleisch AFNICHD NIH HHSNIDDK NIH HHSNIEHS NIH HHSNIAID NIH HHSHarvard School of Public HealthHarvard Pilgrim Health Care InstituteNational Institutes of HealthEnvironmental Protection Agency48-57https://www.ebi.ac.uk/biostudies/studies/S-EPMC4974151biostudies-literatureUnknown12(1)<h4>Background</h4>Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown.<h4>Methods</h4>Among 1418 children in Project Viva, a Boston-area pre-birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid- (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM_2.5 and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics.<h4>Results</h4>Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid-childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid-childhood for children of mothers who lived <50 m vs. ≥200 m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM_2.5 exposure during the year prior was paradoxically associated with improved cardiometabolic profile.<h4>Conclusions</h4>Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.Pediatric obesityPrenatal and early life exposure to traffic pollution and cardiometabolic health in childhood.PMC4974151P01 ES009825P30 DK092924P30 ES000002R01 AI102960K23 ES024803K12 DK094721R37 HD034568R01 HD034568K24HD069408, R37HD034568, P30DK092924, P30ES000002, P01ES009825, R01AI102960, K12DK094721, K23ES024803K24 HD069408RD83479801\Kloog ISchwartz JDZanobetti APerng WOken EMantzoros CSGold DRGillman MWRifas-Shiman SLFleisch AFLuttmann-Gibson HCoull BAKoutrakis PfalsePrenatal and early life exposure to traffic pollution and cardiometabolic health in childhood.<h4>Background</h4>Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown.<h4>Methods</h4>Among 1418 children in Project Viva, a Boston-area pre-birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid- (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM_2.5 and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics.<h4>Results</h4>Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid-childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid-childhood for children of mothers who lived <50 m vs. ≥200 m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM_2.5 exposure during the year prior was paradoxically associated with improved cardiometabolic profile.<h4>Conclusions</h4>Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.2017-01-01T00:00:00Z2017 Feb2025-04-26T22:00:47.24Z2019-03-26T22:59:09ZS-EPMC49741512684335710.1111/ijpo.12106