biostudies-literatureMiranda-CasoLuengo AAscience foundation irelandwellcome trustWellcome Trust553https://www.ebi.ac.uk/biostudies/studies/S-EPMC4974804biostudies-literatureUnknown17<h4>Background</h4>Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant mycobacterium and the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. MAB is also one of the most deadly of the emerging cystic fibrosis (CF) pathogens requiring prolonged treatment with multiple antibiotics. In addition to its "mycobacterial" virulence genes, the genome of MAB harbours a large accessory genome, presumably acquired via lateral gene transfer including homologs shared with the CF pathogens Pseudomonas aeruginosa and Burkholderia cepacia. While multiple genome sequences are available there is little functional genomics data available for this important pathogen.<h4>Results</h4>We report here the first multi-omics approach to characterize the prBMC genomicsFunctional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence.PMC4974804099817/Z/12/Z05/RP1/B908 and 05/RP1/908/EC07Staunton PMLohan AJDinan AMMiranda-CasoLuengo AALoftus BJfalseFunctional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence.<h4>Background</h4>Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant mycobacterium and the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. MAB is also one of the most deadly of the emerging cystic fibrosis (CF) pathogens requiring prolonged treatment with multiple antibiotics. In addition to its "mycobacterial" virulence genes, the genome of MAB harbours a large accessory genome, presumably acquired via lateral gene transfer including homologs shared with the CF pathogens Pseudomonas aeruginosa and Burkholderia cepacia. While multiple genome sequences are available there is little functional genomics data available for this important pathogen.<h4>Results</h4>We report here the first multi-omics approach to characterize the pr2016-01-01T00:00:00Z2016 Aug2026-06-16T05:48:04.342Z2019-06-06T16:11:03ZS-EPMC49748042749516910.1186/s12864-016-2868-y