biostudies-literatureLo NCEuropean Research CouncilStanford University Center for African StudiesDoris Duke Charitable FoundationInfectious Diseases Society of AmericaMount Sinai Hospital-University Health Network AMO Innovation FundAmerican Society of Tropical Medicine and Hygienee0004894https://www.ebi.ac.uk/biostudies/studies/S-EPMC4978437biostudies-literatureUnknown10(8)<h4>Background</h4>A key epidemiologic feature of schistosomiasis is its focal distribution, which has important implications for the spatial targeting of preventive chemotherapy programs. We evaluated the diagnostic accuracy of a urine pooling strategy using a point-of-care circulating cathodic antigen (POC-CCA) cassette test for detection of Schistosoma mansoni, and employed simulation modeling to test the classification accuracy and efficiency of this strategy in determining where preventive chemotherapy is needed in low-endemicity settings.<h4>Methodology</h4>We performed a cross-sectional study involving 114 children aged 6-15 years in six neighborhoods in Azaguié Ahoua, south Côte d'Ivoire to characterize the sensitivity and specificity of the POC-CCA cassette test with urine samplesPLoS neglected tropical diseasesEvaluation of a Urine Pooling Strategy for the Rapid and Cost-Efficient Prevalence Classification of Schistosomiasis.PMC4978437Graduate Student FellowshipMedical Scholars programBenjamin H. Kean Fellowship in Tropical MedicineLo NCBogoch IIKeiser JAndrews JRBendavid ECoulibaly JTUtzinger JN'Goran EKfalseEvaluation of a Urine Pooling Strategy for the Rapid and Cost-Efficient Prevalence Classification of Schistosomiasis.<h4>Background</h4>A key epidemiologic feature of schistosomiasis is its focal distribution, which has important implications for the spatial targeting of preventive chemotherapy programs. We evaluated the diagnostic accuracy of a urine pooling strategy using a point-of-care circulating cathodic antigen (POC-CCA) cassette test for detection of Schistosoma mansoni, and employed simulation modeling to test the classification accuracy and efficiency of this strategy in determining where preventive chemotherapy is needed in low-endemicity settings.<h4>Methodology</h4>We performed a cross-sectional study involving 114 children aged 6-15 years in six neighborhoods in Azaguié Ahoua, south Côte d'Ivoire to characterize the sensitivity and specificity of the POC-CCA cassette test with urine samples2016-01-01T00:00:00Z2016 Aug2025-05-29T22:27:07.958Z2025-05-29T22:27:07.958ZS-EPMC49784372750495410.1371/journal.pntd.0004894