biostudies-literatureVos JRNCI NIH HHS2553-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC4979233biostudies-literatureUnknown33(23)<h4>Purpose</h4>Recommendations for treating patients who carry a BRCA1/2 gene are mainly based on cumulative lifetime risks (CLTRs) of breast cancer determined from retrospective cohorts. These risks vary widely (27% to 88%), and it is important to understand why. We analyzed the effects of methods of risk estimation and bias correction and of population factors on CLTRs in this retrospective clinical cohort of BRCA1/2 carriers.<h4>Patients and methods</h4>The following methods to estimate the breast cancer risk of BRCA1/2 carriers were identified from the literature: Kaplan-Meier, frailty, and modified segregation analyses with bias correction consisting of including or excluding index patients combined with including or excluding first-degree relatives (FDRs) or different conditional liJournal of clinical oncology : official journal of the American Society of Clinical OncologyBias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers.PMC4979233P01 CA053996Oosterwijk JCMalone KEde Bock GHMourits MJBrohet RMHsu Lde Vries JVos JRfalseBias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers.<h4>Purpose</h4>Recommendations for treating patients who carry a BRCA1/2 gene are mainly based on cumulative lifetime risks (CLTRs) of breast cancer determined from retrospective cohorts. These risks vary widely (27% to 88%), and it is important to understand why. We analyzed the effects of methods of risk estimation and bias correction and of population factors on CLTRs in this retrospective clinical cohort of BRCA1/2 carriers.<h4>Patients and methods</h4>The following methods to estimate the breast cancer risk of BRCA1/2 carriers were identified from the literature: Kaplan-Meier, frailty, and modified segregation analyses with bias correction consisting of including or excluding index patients combined with including or excluding first-degree relatives (FDRs) or different conditional li2015-01-01T00:00:00Z2015 Aug2025-04-21T19:02:07.432Z2019-03-27T02:20:16ZS-EPMC49792332615044610.1200/jco.2014.59.046310.1200/JCO.2014.59.0463