{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Wang G"],"pubmed_abstract":["The present study was (i) to prepare two types of selenium nanoparticles, namely an amorphous form of selenium quantum dots (A-SeQDs) and a crystalline form of selenium quantum dots (C-SeQDs); and (ii) to investigate the nano-bio interactions of A-SeQDs and C-SeQDs in MCF-7, HepG2, HeLa, NIH/3T3, L929 cells and BRL-3A cells. It was found that A-SeQDs could induce the mitochondria-mediated apoptosis, necrosis and death of cells, while C-SeQDs had much weaker effects. This polymorphs-dependent anti-proliferative activity of nano-selenium was scarcely reported. Further investigation demonstrated that A-SeQDs could differentially regulate 61 proteins and several pathways related to stress response, protein synthesis, cell migration and cell cycle, including \"p38 MAPK Signaling\", \"p53 Signaling"],"journal":["Scientific reports"],"pagination":["31427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4981849"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondria-Mediated Protein Regulation Mechanism of Polymorphs-Dependent Inhibition of Nanoselenium on Cancer Cells."],"pmcid":["PMC4981849"],"pubmed_authors":["Yang G","Yang L","Guo Y","Zhu L","Zhang H","Ma X","Wang G","Wang X","Wang K","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondria-Mediated Protein Regulation Mechanism of Polymorphs-Dependent Inhibition of Nanoselenium on Cancer Cells.","description":"The present study was (i) to prepare two types of selenium nanoparticles, namely an amorphous form of selenium quantum dots (A-SeQDs) and a crystalline form of selenium quantum dots (C-SeQDs); and (ii) to investigate the nano-bio interactions of A-SeQDs and C-SeQDs in MCF-7, HepG2, HeLa, NIH/3T3, L929 cells and BRL-3A cells. It was found that A-SeQDs could induce the mitochondria-mediated apoptosis, necrosis and death of cells, while C-SeQDs had much weaker effects. This polymorphs-dependent anti-proliferative activity of nano-selenium was scarcely reported. Further investigation demonstrated that A-SeQDs could differentially regulate 61 proteins and several pathways related to stress response, protein synthesis, cell migration and cell cycle, including \"p38 MAPK Signaling\", \"p53 Signaling","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2026-05-01T00:07:54.404Z","creation":"2019-03-27T02:20:28Z"},"accession":"S-EPMC4981849","cross_references":{"pubmed":["27514819"],"doi":["10.1038/srep31427"]}}