biostudies-literatureUnknown9(4)Tardif JC<h4>Background</h4>Dalcetrapib effects on cardiovascular outcomes are determined by adenylate cyclase 9 gene polymorphisms. Our aim was to determine whether these clinical end point results are also associated with changes in reverse cholesterol transport and inflammation.<h4>Methods and results</h4>Participants of the dal-OUTCOMES and dal-PLAQUE-2 trials were randomly assigned to receive dalcetrapib or placebo in addition to standard care. High-sensitivity C-reactive protein was measured at baseline and at end of study in 5243 patients from dal-OUTCOMES also genotyped for the rs1967309 polymorphism in adenylate cyclase 9. Cholesterol efflux capacity of high-density lipoproteins from J774 macrophages after cAMP stimulation was determined at baseline and 12 months in 171 genotyped patients Circulation. Cardiovascular genetics340-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4982759biostudies-literatureGenotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance With Clinical Outcomes.PMC4982759Feroz Zada YBrodeur MRheaume EBoule MFouodjio RL'Allier PLAlem SDube MPRhainds DGregoire JCMongrain ISchwartz GGProvost SGuertin MCIbrahim RTardif JCOlsson AGfalseGenotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation: Concordance With Clinical Outcomes.<h4>Background</h4>Dalcetrapib effects on cardiovascular outcomes are determined by adenylate cyclase 9 gene polymorphisms. Our aim was to determine whether these clinical end point results are also associated with changes in reverse cholesterol transport and inflammation.<h4>Methods and results</h4>Participants of the dal-OUTCOMES and dal-PLAQUE-2 trials were randomly assigned to receive dalcetrapib or placebo in addition to standard care. High-sensitivity C-reactive protein was measured at baseline and at end of study in 5243 patients from dal-OUTCOMES also genotyped for the rs1967309 polymorphism in adenylate cyclase 9. Cholesterol efflux capacity of high-density lipoproteins from J774 macrophages after cAMP stimulation was determined at baseline and 12 months in 171 genotyped patients 2016-01-01T00:00:00Z2016 Aug2026-06-16T04:56:25.918Z2019-03-27T02:20:31ZS-EPMC49827592741859410.1161/CIRCGENETICS.116.001405