biostudies-literatureUnknown13(1)Enose-Akahata Y<h4>Background</h4>Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1). However, other clinical syndromes typically seen in humans such as a chronic progressive myelopathy have not been observed in nonhuman primates. Little is known aboRetrovirology56https://www.ebi.ac.uk/biostudies/studies/S-EPMC4982997biostudies-literatureDevelopment of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1).PMC4982997Haner BEnose-Akahata YNair GOhayon JJacobson SCaruso BMassoud RCharlip EBillioux BJSwitzer WMfalseDevelopment of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1).<h4>Background</h4>Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1). However, other clinical syndromes typically seen in humans such as a chronic progressive myelopathy have not been observed in nonhuman primates. Little is known abo2016-01-01T00:00:00Z2016 Aug2025-05-29T20:02:53.087Z2019-06-06T16:12:44ZS-EPMC49829972751955310.1186/s12977-016-0290-9