{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["114(12)"],"submitter":["Sorich MJ"],"pubmed_abstract":["<h4>Background</h4>Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC). However, risk factors for proteinuria are poorly defined.<h4>Methods</h4>Data on 1392 mRCC patients using pazopanib or sunitinib were pooled from two Phase-III clinical trials. Risk factors and prognostic effect of on-therapy proteinuria were evaluated by Cox proportional hazards regression.<h4>Results</h4>Any-grade (1-4) and grade 3/4 proteinuria incidence were 15.0% and 3.7%, respectively. Asian ethnicity, diabetes, baseline systolic blood pressure (SBP), pre-existing grade 1 proteinuria and prior nephrectomy were significant independent predictors of either any-grade or grade 3/4 proteinuria. Proteinuria, particularly gr"],"journal":["British journal of cancer"],"pagination":["1313-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4984472"],"repository":["biostudies-literature"],"pubmed_title":["Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data."],"pmcid":["PMC4984472"],"pubmed_authors":["Mangoni AA","Woodman RJ","Kichenadasse G","Sorich MJ","Rowland A"],"additional_accession":[]},"is_claimable":false,"name":"Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data.","description":"<h4>Background</h4>Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC). However, risk factors for proteinuria are poorly defined.<h4>Methods</h4>Data on 1392 mRCC patients using pazopanib or sunitinib were pooled from two Phase-III clinical trials. Risk factors and prognostic effect of on-therapy proteinuria were evaluated by Cox proportional hazards regression.<h4>Results</h4>Any-grade (1-4) and grade 3/4 proteinuria incidence were 15.0% and 3.7%, respectively. Asian ethnicity, diabetes, baseline systolic blood pressure (SBP), pre-existing grade 1 proteinuria and prior nephrectomy were significant independent predictors of either any-grade or grade 3/4 proteinuria. Proteinuria, particularly gr","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2026-05-01T03:45:38.592Z","creation":"2019-03-27T02:20:37Z"},"accession":"S-EPMC4984472","cross_references":{"pubmed":["27228299"],"doi":["10.1038/bjc.2016.147"]}}