{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knosgaard KR"],"funding":["NICHD NIH HHS","NIH"],"pagination":["117-30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4984529"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92"],"pubmed_abstract":["Morphine is commonly used for pain management in preterm neonates. The aims of this study were to compare published models of neonatal pharmacokinetics of morphine and its metabolites with a new dataset, and to combine the characteristics of the best predictive models to design a meta-model for morphine and its metabolites in preterm neonates. Moreover, the concentration-analgesia relationship for morphine in this clinical setting was also investigated. A population of 30 preterm neonates (gestational age: 23-32weeks) received a loading dose of morphine (50-100μg/kg), followed by a continuous infusion (5-10μg/kg/h) until analgesia was no longer required. Pain was assessed using the Premature Infant Pain Profile. Five published population models were compared using numerical and graphical t"],"journal":["European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences"],"pubmed_title":["Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model."],"pmcid":["PMC4984529"],"funding_grant_id":["R01HD048689","R01 HD048689"],"pubmed_authors":["Knosgaard KR","Foster DJ","Kreilgaard M","van den Anker JN","Sverrisdottir E","Upton RN"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model.","description":"Morphine is commonly used for pain management in preterm neonates. The aims of this study were to compare published models of neonatal pharmacokinetics of morphine and its metabolites with a new dataset, and to combine the characteristics of the best predictive models to design a meta-model for morphine and its metabolites in preterm neonates. Moreover, the concentration-analgesia relationship for morphine in this clinical setting was also investigated. A population of 30 preterm neonates (gestational age: 23-32weeks) received a loading dose of morphine (50-100μg/kg), followed by a continuous infusion (5-10μg/kg/h) until analgesia was no longer required. Pain was assessed using the Premature Infant Pain Profile. Five published population models were compared using numerical and graphical t","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-25T22:38:25.978Z","creation":"2019-03-27T02:20:37Z"},"accession":"S-EPMC4984529","cross_references":{"pubmed":["27373670"],"doi":["10.1016/j.ejps.2016.06.026"]}}