biostudies-literatureKnosgaard KRNICHD NIH HHSNIH117-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC4984529biostudies-literatureUnknown92Morphine is commonly used for pain management in preterm neonates. The aims of this study were to compare published models of neonatal pharmacokinetics of morphine and its metabolites with a new dataset, and to combine the characteristics of the best predictive models to design a meta-model for morphine and its metabolites in preterm neonates. Moreover, the concentration-analgesia relationship for morphine in this clinical setting was also investigated. A population of 30 preterm neonates (gestational age: 23-32weeks) received a loading dose of morphine (50-100μg/kg), followed by a continuous infusion (5-10μg/kg/h) until analgesia was no longer required. Pain was assessed using the Premature Infant Pain Profile. Five published population models were compared using numerical and graphical tEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesPharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model.PMC4984529R01HD048689R01 HD048689Knosgaard KRFoster DJKreilgaard Mvan den Anker JNSverrisdottir EUpton RNfalsePharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model.Morphine is commonly used for pain management in preterm neonates. The aims of this study were to compare published models of neonatal pharmacokinetics of morphine and its metabolites with a new dataset, and to combine the characteristics of the best predictive models to design a meta-model for morphine and its metabolites in preterm neonates. Moreover, the concentration-analgesia relationship for morphine in this clinical setting was also investigated. A population of 30 preterm neonates (gestational age: 23-32weeks) received a loading dose of morphine (50-100μg/kg), followed by a continuous infusion (5-10μg/kg/h) until analgesia was no longer required. Pain was assessed using the Premature Infant Pain Profile. Five published population models were compared using numerical and graphical t2016-01-01T00:00:00Z2016 Sep2025-04-25T22:38:25.978Z2019-03-27T02:20:37ZS-EPMC49845292737367010.1016/j.ejps.2016.06.026