{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Estrada-Florez AP"],"funding":["NCI NIH HHS"],"pagination":["e4148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4985291"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(32)"],"pubmed_abstract":["Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population.We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KAS"],"journal":["Medicine"],"pubmed_title":["Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk."],"pmcid":["PMC4985291"],"funding_grant_id":["P30 CA093373","R21 CA199631","K12 CA138464"],"pubmed_authors":["Sahasrabudhe R","Velez A","Lott P","Carvajal-Carmona LG","Estrada-Florez AP","Mateus G","Bolanos F","Duque CS","Bohorquez ME","Prieto R","Donado J","Echeverry M"],"additional_accession":[]},"is_claimable":false,"name":"Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk.","description":"Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population.We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KAS","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2026-05-01T03:50:43.669Z","creation":"2026-04-07T16:40:36.653Z"},"accession":"S-EPMC4985291","cross_references":{"pubmed":["27512836"],"doi":["10.1097/MD.0000000000004148"]}}