{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Kim J"],"pubmed_abstract":["Single-Si-nanowire (NW)-based DNA sensors have been recently developed, but their sensitivity is very limited because of high noise signals, originating from small source-drain current of the single Si NW. Here, we demonstrate that chemical-vapor-deposition-grown large-scale graphene/surface-modified vertical-Si-NW-arrays junctions can be utilized as diode-type biosensors for highly-sensitive and -selective detection of specific oligonucleotides. For this, a twenty-seven-base-long synthetic oligonucleotide, which is a fragment of human DENND2D promoter sequence, is first decorated as a probe on the surface of vertical Si-NW arrays, and then the complementary oligonucleotide is hybridized to the probe. This hybridization gives rise to a doping effect on the surface of Si NWs, resulting in t"],"journal":["Scientific reports"],"pagination":["31984"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4989226"],"repository":["biostudies-literature"],"pubmed_title":["Precise and selective sensing of DNA-DNA hybridization by graphene/Si-nanowires diode-type biosensors."],"pmcid":["PMC4989226"],"pubmed_authors":["Kim S","Kim JM","Kang H","Han JS","Park JW","Choi SH","Lee DH","Kim JH","Lee H","Kim J","Park SY"],"additional_accession":[]},"is_claimable":false,"name":"Precise and selective sensing of DNA-DNA hybridization by graphene/Si-nanowires diode-type biosensors.","description":"Single-Si-nanowire (NW)-based DNA sensors have been recently developed, but their sensitivity is very limited because of high noise signals, originating from small source-drain current of the single Si NW. Here, we demonstrate that chemical-vapor-deposition-grown large-scale graphene/surface-modified vertical-Si-NW-arrays junctions can be utilized as diode-type biosensors for highly-sensitive and -selective detection of specific oligonucleotides. For this, a twenty-seven-base-long synthetic oligonucleotide, which is a fragment of human DENND2D promoter sequence, is first decorated as a probe on the surface of vertical Si-NW arrays, and then the complementary oligonucleotide is hybridized to the probe. This hybridization gives rise to a doping effect on the surface of Si NWs, resulting in t","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-04-04T11:54:19.837Z","creation":"2019-03-27T02:20:56Z"},"accession":"S-EPMC4989226","cross_references":{"pubmed":["27534818"],"doi":["10.1038/srep31984"]}}