biostudies-literatureUnknown6Kim JSingle-Si-nanowire (NW)-based DNA sensors have been recently developed, but their sensitivity is very limited because of high noise signals, originating from small source-drain current of the single Si NW. Here, we demonstrate that chemical-vapor-deposition-grown large-scale graphene/surface-modified vertical-Si-NW-arrays junctions can be utilized as diode-type biosensors for highly-sensitive and -selective detection of specific oligonucleotides. For this, a twenty-seven-base-long synthetic oligonucleotide, which is a fragment of human DENND2D promoter sequence, is first decorated as a probe on the surface of vertical Si-NW arrays, and then the complementary oligonucleotide is hybridized to the probe. This hybridization gives rise to a doping effect on the surface of Si NWs, resulting in tScientific reports31984https://www.ebi.ac.uk/biostudies/studies/S-EPMC4989226biostudies-literaturePrecise and selective sensing of DNA-DNA hybridization by graphene/Si-nanowires diode-type biosensors.PMC4989226Kim SKim JMKang HHan JSPark JWChoi SHLee DHKim JHLee HKim JPark SYfalsePrecise and selective sensing of DNA-DNA hybridization by graphene/Si-nanowires diode-type biosensors.Single-Si-nanowire (NW)-based DNA sensors have been recently developed, but their sensitivity is very limited because of high noise signals, originating from small source-drain current of the single Si NW. Here, we demonstrate that chemical-vapor-deposition-grown large-scale graphene/surface-modified vertical-Si-NW-arrays junctions can be utilized as diode-type biosensors for highly-sensitive and -selective detection of specific oligonucleotides. For this, a twenty-seven-base-long synthetic oligonucleotide, which is a fragment of human DENND2D promoter sequence, is first decorated as a probe on the surface of vertical Si-NW arrays, and then the complementary oligonucleotide is hybridized to the probe. This hybridization gives rise to a doping effect on the surface of Si NWs, resulting in t2016-01-01T00:00:00Z2016 Aug2025-04-04T11:54:19.837Z2019-03-27T02:20:56ZS-EPMC49892262753481810.1038/srep31984