{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Igarashi Y"],"funding":["the Japan Society for the Promotion of Science","the Urakami Foundation for Food and Food Culture Promotion"],"pagination":["e0161282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4990220"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["Zerumbone is a sesquiterpene present in Zinger zerumbet. Many studies have demonstrated its marked anti-inflammatory and anti-carcinogenesis activities. Recently, we showed that zerumbone binds to numerous proteins with scant selectivity and induces the expression of heat shock proteins (HSPs) in hepatocytes. To dampen proteo-toxic stress, organisms have a stress-responsive molecular machinery, known as heat shock response. Heat shock factor 1 (HSF1) plays a key role in this protein quality control system by promoting activation of HSPs. In this study, we investigated whether zerumbone-induced HSF1 activation contributes to its anti-inflammatory functions in stimulated macrophages. Our findings showed that zerumbone increased cellular protein aggregates and promoted nuclear translocation o"],"journal":["PloS one"],"pubmed_title":["Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1."],"pmcid":["PMC4990220"],"funding_grant_id":["22.3355","26450156"],"pubmed_authors":["Ohnishi K","Igarashi Y","Irie K","Murakami A"],"additional_accession":[]},"is_claimable":false,"name":"Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.","description":"Zerumbone is a sesquiterpene present in Zinger zerumbet. Many studies have demonstrated its marked anti-inflammatory and anti-carcinogenesis activities. Recently, we showed that zerumbone binds to numerous proteins with scant selectivity and induces the expression of heat shock proteins (HSPs) in hepatocytes. To dampen proteo-toxic stress, organisms have a stress-responsive molecular machinery, known as heat shock response. Heat shock factor 1 (HSF1) plays a key role in this protein quality control system by promoting activation of HSPs. In this study, we investigated whether zerumbone-induced HSF1 activation contributes to its anti-inflammatory functions in stimulated macrophages. Our findings showed that zerumbone increased cellular protein aggregates and promoted nuclear translocation o","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-04T11:55:24.399Z","creation":"2019-03-26T22:54:10Z"},"accession":"S-EPMC4990220","cross_references":{"pubmed":["27536885"],"doi":["10.1371/journal.pone.0161282"]}}