biostudies-literatureDowling CMNIGMS NIH HHS20919-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC4991501biostudies-literatureUnknown7(15)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some cases, worsened disease outcome. Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but patients with low levels of this isozyme have significantly decreased disease free survival. Specifically, analysis of gene expression levels of all PKC genes in matched normal and cancer tissue samples from colon cancer patients revealed a striking down-regulation of the gene coding PKC Beta in the cancer tissue (n = 21). Tissue microarray analysis revealed a dramatic down-regulation of PKC Beta II protein levels in both the epithelial and OncotargetProtein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.PMC4991501R01 GM043154T32 GM007752R37 GM043154Callender JACathcart MCKiely PACoffey JCDalton TMehigan BO'Sullivan JPhelan JNewton ACMcCormick PDowling CMfalseProtein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some cases, worsened disease outcome. Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but patients with low levels of this isozyme have significantly decreased disease free survival. Specifically, analysis of gene expression levels of all PKC genes in matched normal and cancer tissue samples from colon cancer patients revealed a striking down-regulation of the gene coding PKC Beta in the cancer tissue (n = 21). Tissue microarray analysis revealed a dramatic down-regulation of PKC Beta II protein levels in both the epithelial and 2016-01-01T00:00:00Z2016 Apr2025-05-18T12:45:49.989Z2025-05-18T12:45:49.989ZS-EPMC49915012698902410.18632/oncotarget.8062