biostudies-literatureKe TNational University of SingaporeNational Research Foundation SingaporeNCI NIH HHSNational Medical Research CouncilNational Institutes of Health282-93https://www.ebi.ac.uk/biostudies/studies/S-EPMC4991635biostudies-literatureUnknown80(5)Peroxisome proliferator activated receptors (PPARs) are transcription factors involved in the regulation of key metabolic pathways. Numerous in vivo and in vitro studies have established their important roles in lipid metabolism. A few SNPs in PPAR genes have been reported to be associated with lipid levels. In this study, we aimed to investigate the interactive effects between single nucleotide polymorphisms (SNPs) in three PPAR isoforms α/δ/γ and other genetic variants across the genome on plasma high-density lipoprotein-cholesterol (HDL-C) levels. Study subjects (N = 2003) were genotyped using Illumina HumanOmniZhongHua-8 Beadchip. Fifty-three tag SNPs ± 100 kb of PPAR α, δ, and γ (r(2) < 0.2) were selected. The effect of interactions between PPAR SNPs and those across the genome on HDLAnnals of human geneticsInteraction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.PMC4991635R01 CA1440340796/2003UM1 CA182876370062002NMRC/1270/2010CSA/033/2012STaR/2008CG 2010IRG07nov013IRG09nov014STaR/2013;CG 2013Yuan JMGoh DYLiu JDorajoo RHeng CKHan Yvan Dam RMTai ESKe TCheng CYWong TYKoh WPKhor CCTeo YYFriedlander YfalseInteraction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.Peroxisome proliferator activated receptors (PPARs) are transcription factors involved in the regulation of key metabolic pathways. Numerous in vivo and in vitro studies have established their important roles in lipid metabolism. A few SNPs in PPAR genes have been reported to be associated with lipid levels. In this study, we aimed to investigate the interactive effects between single nucleotide polymorphisms (SNPs) in three PPAR isoforms α/δ/γ and other genetic variants across the genome on plasma high-density lipoprotein-cholesterol (HDL-C) levels. Study subjects (N = 2003) were genotyped using Illumina HumanOmniZhongHua-8 Beadchip. Fifty-three tag SNPs ± 100 kb of PPAR α, δ, and γ (r(2) < 0.2) were selected. The effect of interactions between PPAR SNPs and those across the genome on HDL2016-01-01T00:00:00Z2016 Sep2026-04-29T02:02:00.005Z2019-03-27T02:21:05ZS-EPMC49916352753044910.1111/ahg.12164