{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Begemann I"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4993758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Many core paradigms of contemporary neuroscience are based on information obtained by electron or light microscopy. Intriguingly, these two imaging techniques are often viewed as complementary, yet separate entities. Recent technological advancements in microscopy techniques, labeling tools, and fixation or preparation procedures have fueled the development of a series of hybrid approaches that allow correlating functional fluorescence microscopy data and ultrastructural information from electron micrographs from a singular biological event. As correlative light electron microscopy (CLEM) approaches become increasingly accessible, long-standing neurobiological questions regarding structure-function relation are being revisited. In this review, we will survey what developments in electron a"],"journal":["Frontiers in synaptic neuroscience"],"pubmed_title":["Correlative Light Electron Microscopy: Connecting Synaptic Structure and Function."],"pmcid":["PMC4993758"],"funding_grant_id":["EXC-1003"],"pubmed_authors":["Begemann I","Galic M"],"additional_accession":[]},"is_claimable":false,"name":"Correlative Light Electron Microscopy: Connecting Synaptic Structure and Function.","description":"Many core paradigms of contemporary neuroscience are based on information obtained by electron or light microscopy. Intriguingly, these two imaging techniques are often viewed as complementary, yet separate entities. Recent technological advancements in microscopy techniques, labeling tools, and fixation or preparation procedures have fueled the development of a series of hybrid approaches that allow correlating functional fluorescence microscopy data and ultrastructural information from electron micrographs from a singular biological event. As correlative light electron microscopy (CLEM) approaches become increasingly accessible, long-standing neurobiological questions regarding structure-function relation are being revisited. In this review, we will survey what developments in electron a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-18T18:08:14.57Z","creation":"2019-03-27T02:21:13Z"},"accession":"S-EPMC4993758","cross_references":{"pubmed":["27601992"],"doi":["10.3389/fnsyn.2016.00028"]}}