{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Bertini A"],"pubmed_abstract":["Candida parapsilosis is an emerging opportunistic pathogen, second in frequency only to C. albicans and commonly associated with both mucosal and systemic infections. Adhesion to biotic surfaces is a key step for the development of mycoses. The C. parapsilosis genome encodes 5 predicted agglutinin-like sequence proteins and their precise role in the adhesion process still remains to be elucidated. In this study, we focused on the putative adhesin Cpar2_404800, in view of its high homology to the most important adhesion molecule in C. albicans. Two independent lineages of C. parapsilosis CPAR2_404800 heterozygous and null mutants were obtained by site-specific deletion. CPAR2_404800 mutants did not differ from wild-type strain in terms of in vitro growth or in their ability to undergo morph"],"journal":["Virulence"],"pagination":["85-97"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4994826"],"repository":["biostudies-literature"],"pubmed_title":["Targeted gene disruption in Candida parapsilosis demonstrates a role for CPAR2_404800 in adhesion to a biotic surface and in a murine model of ascending urinary tract infection."],"pmcid":["PMC4994826"],"pubmed_authors":["Lombardi L","Rizzato C","De Carolis E","Vella A","Torelli R","Sanguinetti M","Tavanti A","Zoppo M","Bertini A"],"additional_accession":[]},"is_claimable":false,"name":"Targeted gene disruption in Candida parapsilosis demonstrates a role for CPAR2_404800 in adhesion to a biotic surface and in a murine model of ascending urinary tract infection.","description":"Candida parapsilosis is an emerging opportunistic pathogen, second in frequency only to C. albicans and commonly associated with both mucosal and systemic infections. Adhesion to biotic surfaces is a key step for the development of mycoses. The C. parapsilosis genome encodes 5 predicted agglutinin-like sequence proteins and their precise role in the adhesion process still remains to be elucidated. In this study, we focused on the putative adhesin Cpar2_404800, in view of its high homology to the most important adhesion molecule in C. albicans. Two independent lineages of C. parapsilosis CPAR2_404800 heterozygous and null mutants were obtained by site-specific deletion. CPAR2_404800 mutants did not differ from wild-type strain in terms of in vitro growth or in their ability to undergo morph","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-08T01:58:29.561Z","creation":"2019-06-06T16:15:06Z"},"accession":"S-EPMC4994826","cross_references":{"pubmed":["26632333"],"doi":["10.1080/21505594.2015.1112491"]}}