biostudies-literatureChailangkarn TNIMH NIH HHSNIDCD NIH HHSNIH HHSPHS HHS338-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC4995142biostudies-literatureUnknown536(7616)Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1-5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains largely unexplored. Here we investigate neural progenitor cells and cortical neurons derived from Williams syndrome and typically developing induced pluripotent stem cells. Neural progenitor cells in Williams syndrome have an increased doubling time and apoptosis compared with typically developing neural progenitor NatureA human neurodevelopmental model for Williams syndrome.PMC4995142R56 MH109587U19MH1073671-DP2-OD006495-01R01MH094753U19MH106434R01MH095741DP2 OD006495R01 MH094753T32 MH020002R01MH103134U19 MH107367T32 DC007361P01 NICHD033113R01 MH100175R01 MH103134Bellugi UHalgren ESearcy YMMarchetto MCMuotri ARDeWitt MFreitas BCRomero SStefanacci LHerai RHYu DXTrujillo CAKorenberg JRMcHenry LWong WHanson KLGage FHChailangkarn TJarvinen ADai LSemendeferi KBrown TTHrvoj-Mihic BLai PDale AMJacobs BBardy CArd MCfalseA human neurodevelopmental model for Williams syndrome.Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1-5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains largely unexplored. Here we investigate neural progenitor cells and cortical neurons derived from Williams syndrome and typically developing induced pluripotent stem cells. Neural progenitor cells in Williams syndrome have an increased doubling time and apoptosis compared with typically developing neural progenitor 2016-01-01T00:00:00Z2016 Aug2026-05-01T03:56:42.497Z2026-04-07T16:39:45.995ZS-EPMC49951422750985010.1038/nature19067