{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(8)"],"submitter":["Drolez A"],"pubmed_abstract":["The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34⁺ derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier."],"journal":["International journal of molecular sciences"],"pagination":["E1309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5000706"],"repository":["biostudies-literature"],"pubmed_title":["ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier."],"pmcid":["PMC5000706"],"pubmed_authors":["Drolez A","Dewald JH","Delannoy P","Dehouck MP","Julien S","Vandenhaute E","Cecchelli R","Mysiorek C","Delannoy CP","Gosselet F"],"additional_accession":[]},"is_claimable":false,"name":"ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.","description":"The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34⁺ derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-04-04T11:56:01.456Z","creation":"2019-03-27T02:22:46Z"},"accession":"S-EPMC5000706","cross_references":{"pubmed":["27529215"],"doi":["10.3390/ijms17081309"]}}