biostudies-literatureLerchenmuller CNCATS NIH HHSNHLBI NIH HHS1854-67https://www.ebi.ac.uk/biostudies/studies/S-EPMC5001879biostudies-literatureUnknown36(9)<h4>Objective</h4>S100A6, a member of the S100 protein family, has been described as relevant for cell cycle entry and progression in endothelial cells. The molecular mechanism conferring S100A6's proliferative actions, however, remained elusive.<h4>Approach and results</h4>Originating from the clinically relevant observation of enhanced S100A6 protein expression in proliferating endothelial cells in remodeling coronary and carotid arteries, our study unveiled S100A6 as a suppressor of antiproliferative signal transducers and activators of transcription 1 signaling. Discovery of the molecular liaison was enabled by combining gene expression time series analysis with bioinformatic pathway modeling in S100A6-silenced human endothelial cells stimulated with vascular endothelial growth factor Arteriosclerosis, thrombosis, and vascular biologyS100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling.PMC5001879UL1 TR001102T32 HL007374Lerchenmuller CDamilano FMost PBochaton-Piallat MLBusch HPeppel KHeißenberg JBezzeridis VJRosenzweig AKatus HABoerries MBusch MHirschberg KKramer IfalseS100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling.<h4>Objective</h4>S100A6, a member of the S100 protein family, has been described as relevant for cell cycle entry and progression in endothelial cells. The molecular mechanism conferring S100A6's proliferative actions, however, remained elusive.<h4>Approach and results</h4>Originating from the clinically relevant observation of enhanced S100A6 protein expression in proliferating endothelial cells in remodeling coronary and carotid arteries, our study unveiled S100A6 as a suppressor of antiproliferative signal transducers and activators of transcription 1 signaling. Discovery of the molecular liaison was enabled by combining gene expression time series analysis with bioinformatic pathway modeling in S100A6-silenced human endothelial cells stimulated with vascular endothelial growth factor 2016-01-01T00:00:00Z2016 Sep2026-04-29T01:12:11.525Z2019-03-27T02:22:49ZS-EPMC50018792738693810.1161/ATVBAHA.115.30641510.1161/atvbaha.115.306415